NCCN Quick Guide™ | Hepatobiliary Cancers

2 of 2 NCCN QUICK GUIDE tm Hepatobiliary Cancers, 2018 PAT-N-1054-0618 What are the treatment options for HCC? Surgery or a liver transplant are primary (main) treatment options for people with HCC. 43 Sometimes HCC can’t be removed by surgery (partial hepatectomy) for a few reasons. A liver transplant may be possible in some cases. 44 If a liver transplant is not the best option, you may receive ablation, ADT ( a ndrogen d eprivation t herapy), or radiation therapy. Systemic therapy using drug treatment may also be an option. Other options include a clinical trial or best supportive care. 45 Treatment options for HCC that has spread to distant sites in the body or for many tumors throughout the liver include systemic therapy with sorafenib or chemotherapy, a clinical trial, or best supportive care. 46 What are the treatment options for gallbladder cancer? For most, the surgery will involve taking out more than the gallbladder. Your doctor may also remove a section or whole lobe of the liver, some lymph nodes, and possibly the common bile duct. 49 Other treatment options may be suggested. They include chemotherapy, chemoradiation, radiation therapy, a clinical trial, best supportive care, or pembrolizumab for MSI-H ( m icro s atellite i nstability- h igh) tumors. If you have jaundice, your doctor will consider surgery. If surgery is not an option, your doctor may suggest draining the fluid, chemotherapy, chemoradiation, radiation therapy, a clinical trial, best supportive care, or pembrolizumab for MSI-H tumors. 53 What are the treatment options for bile duct cancers? Intrahepatic bile duct cancer First, your treatment team will assess if surgery is an option. If surgery can’t be done, options include chemotherapy, a clinical trial, chemoradiation, locoregional therapies, pembrolizumab for MSI-H tumors, or best supportive care. 58 Extrahepatic bile duct cancer Your treatment team will consider surgery and biliary drainage. If this is not the best first option, you may have chemotherapy, a clinical trial, chemoradiation, radiation therapy, pembrolizumab for MSI-H tumors, or best supportive care. 62 How do I decide between options? Ask your doctors many questions. You can also get a second opinion, attend support groups, and compare the benefits and possible risks. 66 NCCN Guidelines for Patients ® Page Number Ü NCCN.org/patients - for Patients | NCCN.org - for Clinicians The NCCN QUICK GUIDE tm series and NCCN Guidelines for Patients ® are supported by charitable donations made to the NCCN Foundation ® . For more details and the full library of patient and caregiver resources, visit NCCN.org/patients. DONATE NOW NCCNFoundation.org/Donate

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