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NCCN Guidelines® & Clinical Resources

NCCN Harmonized Guidelines™ for Sub-Saharan Africa

Clinicians around the world use NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) as a standard for clinical decision-making. As part of a joint project with the African Cancer Coalition (ACC), American Cancer Society (ACS), and the Clinton Health Access Initiative (CHAI), NCCN and members of ACC adapted the NCCN Guidelines® to create the NCCN Harmonized Guidelines™ for Sub-Saharan Africa. These Guidelines represent both the optimal care that these countries aspire to provide and pragmatic approaches that provide effective treatment options for resource-constrained settings.

The initial offering consists of eight Guidelines for cancer treatment and supportive care; additional Harmonized Guidelines will be published in 2018.

Using the Harmonized Guidelines

Recommendations within the NCCN Harmonized Guidelines™ for Sub-Saharan Africa are represented using the following system:

  • Black Text: Generally available standard of care
  • Gray Text: Highly advanced/optimal care that may be costly, technically challenging, and/or have a lesser impact on oncologic outcome
  • Blue Text: Regional options that may be considered when availability precludes general standard of care

About the Collaboration

The goal of this collaboration is to implement the NCCN Harmonized Guidelines™ along with training of an expanded group of cancer care providers to improve the availability of effective therapies for patients with cancer in Africa.

Key to the success of this effort has been the involvement of experts from Africa. More than 40 African Cancer Coalition members from 12 countries in Sub-Saharan Africa have participated in the adaptation process, including clinical oncologists, educators, representatives from health ministries, and health care administrators. This initiative spans national borders in Africa and spans continents in a collaborative effort. The knowledge that the ACC individuals bring to the table is extensive and invaluable. They know the challenges and many solutions to delivering cancer care in resource-constrained environments. Any success in the effort to improve oncology care in Africa is largely thanks to the dedication and participation of NCCN’s African colleagues.

For more information about NCCN’s collaboration to create the NCCN Harmonized Guidelines™ for Sub-Saharan Africa, visit

NCCN Harmonized Guidelines™ for Sub-Saharan Africa

NCCN Harmonized Guidelines™ for Sub-Saharan Africa is copyrighted by NCCN. All rights reserved. NCCN Content may not be reproduced in any form for any purpose without the express written permission of NCCN. Permissions Requests Section